Physicochemical characterization of lycopene-loaded nanostructured lipid carrier formulations for topical administration.
Identifieur interne : 000500 ( Main/Exploration ); précédent : 000499; suivant : 000501Physicochemical characterization of lycopene-loaded nanostructured lipid carrier formulations for topical administration.
Auteurs : Siriporn Okonogi [Thaïlande] ; Pornthida Riangjanapatee [Thaïlande]Source :
- International journal of pharmaceutics [ 1873-3476 ] ; 2015.
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Antioxidants, Carotenoids, Drug Carriers, Glutamates, Plant Oils, Waxes.
- chemistry : Nanostructures.
- Administration, Topical, Chemistry, Pharmaceutical, Citrus sinensis, Drug Liberation, Drug Stability, Particle Size.
Abstract
Nanostructured lipid carriers (NLC) are interesting delivery systems for enhancing the penetration of an active substance through the skin after topical administration. In the present study, lycopene was loaded into NLC, composed of Eumulgin(®) SG, orange wax and rice bran oil, using high pressure homogenization (HPH). Photon correlation spectroscopy analysis showed that the lycopene-loaded NLC had a size of 150-160nm with a relatively small size distribution (PdI<0.15). The entrapment efficiency of lycopene was found to be 100±0% for all formulations. An in vitro release study of lycopene showed a biphasic release profile: a relatively fast release during the first 6h followed by a sustained release during the next 18h. An in vitro occlusion test showed that the occlusive properties of NLC increased with increasing lycopene loading. A free radical scavenging activity test of the NLC loaded with 50mg% lycopene showed a Trolox equivalent antioxidant capacity value of 36.6±0.4μM Trolox/mg NLC which is higher than that of the NLC base (26.6±0.1μM Trolox/mg NLC). The concentration of 50% antioxidant activity (IC50) of the lycopene-loaded NLC was 14.1±0.6mg/mL, and lower than that of the formulation without lycopene (17.7±0.4mg/mL). The particle size, size distribution, and zeta potential of lycopene-loaded NLC stored at different temperatures of 4, 30, 40°C for 120 days did not change in time, demonstrating an excellent colloidal stability of the systems. Chemical stability data indicated that the utilization of NLC increased the stability of lycopene and it was found that the degradation of lycopene was retarded when stored at low temperatures. In conclusion, NLC are attractive systems for the cutaneous delivery of lycopene.
DOI: 10.1016/j.ijpharm.2014.12.002
PubMed: 25479097
Affiliations:
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Electronic address: siriporn.okonogi@cmu.ac.th.</nlm:affiliation><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200</wicri:regionArea><wicri:noRegion>Chiang Mai 50200</wicri:noRegion></affiliation></author><author><name sortKey="Riangjanapatee, Pornthida" sort="Riangjanapatee, Pornthida" uniqKey="Riangjanapatee P" first="Pornthida" last="Riangjanapatee">Pornthida Riangjanapatee</name><affiliation wicri:level="1"><nlm:affiliation>National Nanotechnology Center, National Science and Technology Development Agency (NSTDA), Pathum Thani 12120, Thailand.</nlm:affiliation><country xml:lang="fr">Thaïlande</country><wicri:regionArea>National Nanotechnology Center, National Science and Technology Development Agency (NSTDA), Pathum Thani 12120</wicri:regionArea><wicri:noRegion>Pathum Thani 12120</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25479097</idno><idno type="pmid">25479097</idno><idno type="doi">10.1016/j.ijpharm.2014.12.002</idno><idno type="wicri:Area/PubMed/Corpus">000230</idno><idno type="wicri:Area/PubMed/Curation">000230</idno><idno type="wicri:Area/PubMed/Checkpoint">000230</idno><idno type="wicri:Area/Ncbi/Merge">001940</idno><idno type="wicri:Area/Ncbi/Curation">001940</idno><idno type="wicri:Area/Ncbi/Checkpoint">001940</idno><idno type="wicri:Area/Main/Merge">000500</idno><idno type="wicri:Area/Main/Curation">000500</idno><idno type="wicri:Area/Main/Exploration">000500</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Physicochemical characterization of lycopene-loaded nanostructured lipid carrier formulations for topical administration.</title><author><name sortKey="Okonogi, Siriporn" sort="Okonogi, Siriporn" uniqKey="Okonogi S" first="Siriporn" last="Okonogi">Siriporn Okonogi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand. Electronic address: siriporn.okonogi@cmu.ac.th.</nlm:affiliation><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200</wicri:regionArea><wicri:noRegion>Chiang Mai 50200</wicri:noRegion></affiliation></author><author><name sortKey="Riangjanapatee, Pornthida" sort="Riangjanapatee, Pornthida" uniqKey="Riangjanapatee P" first="Pornthida" last="Riangjanapatee">Pornthida Riangjanapatee</name><affiliation wicri:level="1"><nlm:affiliation>National Nanotechnology Center, National Science and Technology Development Agency (NSTDA), Pathum Thani 12120, Thailand.</nlm:affiliation><country xml:lang="fr">Thaïlande</country><wicri:regionArea>National Nanotechnology Center, National Science and Technology Development Agency (NSTDA), Pathum Thani 12120</wicri:regionArea><wicri:noRegion>Pathum Thani 12120</wicri:noRegion></affiliation></author></analytic><series><title level="j">International journal of pharmaceutics</title><idno type="eISSN">1873-3476</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Topical</term><term>Antioxidants (chemistry)</term><term>Carotenoids (chemistry)</term><term>Chemistry, Pharmaceutical</term><term>Citrus sinensis</term><term>Drug Carriers (chemistry)</term><term>Drug Liberation</term><term>Drug Stability</term><term>Glutamates (chemistry)</term><term>Nanostructures (chemistry)</term><term>Particle Size</term><term>Plant Oils (chemistry)</term><term>Waxes (chemistry)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antioxidants</term><term>Carotenoids</term><term>Drug Carriers</term><term>Glutamates</term><term>Plant Oils</term><term>Waxes</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Nanostructures</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Topical</term><term>Chemistry, Pharmaceutical</term><term>Citrus sinensis</term><term>Drug Liberation</term><term>Drug Stability</term><term>Particle Size</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Nanostructured lipid carriers (NLC) are interesting delivery systems for enhancing the penetration of an active substance through the skin after topical administration. In the present study, lycopene was loaded into NLC, composed of Eumulgin(®) SG, orange wax and rice bran oil, using high pressure homogenization (HPH). Photon correlation spectroscopy analysis showed that the lycopene-loaded NLC had a size of 150-160nm with a relatively small size distribution (PdI<0.15). The entrapment efficiency of lycopene was found to be 100±0% for all formulations. An in vitro release study of lycopene showed a biphasic release profile: a relatively fast release during the first 6h followed by a sustained release during the next 18h. An in vitro occlusion test showed that the occlusive properties of NLC increased with increasing lycopene loading. A free radical scavenging activity test of the NLC loaded with 50mg% lycopene showed a Trolox equivalent antioxidant capacity value of 36.6±0.4μM Trolox/mg NLC which is higher than that of the NLC base (26.6±0.1μM Trolox/mg NLC). The concentration of 50% antioxidant activity (IC50) of the lycopene-loaded NLC was 14.1±0.6mg/mL, and lower than that of the formulation without lycopene (17.7±0.4mg/mL). The particle size, size distribution, and zeta potential of lycopene-loaded NLC stored at different temperatures of 4, 30, 40°C for 120 days did not change in time, demonstrating an excellent colloidal stability of the systems. Chemical stability data indicated that the utilization of NLC increased the stability of lycopene and it was found that the degradation of lycopene was retarded when stored at low temperatures. In conclusion, NLC are attractive systems for the cutaneous delivery of lycopene.</div></front></TEI><affiliations><list><country><li>Thaïlande</li></country></list><tree><country name="Thaïlande"><noRegion><name sortKey="Okonogi, Siriporn" sort="Okonogi, Siriporn" uniqKey="Okonogi S" first="Siriporn" last="Okonogi">Siriporn Okonogi</name></noRegion><name sortKey="Riangjanapatee, Pornthida" sort="Riangjanapatee, Pornthida" uniqKey="Riangjanapatee P" first="Pornthida" last="Riangjanapatee">Pornthida Riangjanapatee</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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